Benzamycin (Erythromycin 3%-benzoyl peroxide 5% topical gel) Company

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BENZAMYCIN 
(Erythromycin 3%-benzoyl peroxide 5% topical gel) 
Company: 
Dermik Laboratories 
Approval Status: 
Approved November 2000 
Treatment for: 
Acne vulgaris 
Benzamycin 
is a combination of two active ingredients, benzoic peroxide and
 
erythromycin, which has proven effective in stopping acne-causing bacteria and 
reducing acne infection. Erythromycin is an antibiotic produced from a strain of 
Saccharopolyspora erythraea
, whereas benzoic peroxide is an antibacterial and 
keratolytic agent (causes the break down of keratin). 
The term "acne vulgaris" refers to the more common form of acne, consisting of 
non-inflammatory and mildly inflammatory lesions. The more severe form of acne 
is characterized by the presence of nodules. Nearly 17 million people in the United 
States have acne, making it the most common skin disease. Although acne is not a 
serious health threat, severe acne can lead to disfiguring, permanent scarring, 
which can be upsetting for people who suffer from the disorder. 
Side Effects 
Adverse reactions reported occasionally or associated with the use of Benzamycin 
Topical Gel include the following: 
Dryness
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Urticarial reaction (hives, itching)
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Peeling
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Burning sensation
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Inflammation of the face, eyes, and nose
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Skin discoloration
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Oiliness
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Tenderness of the skin
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Mechanism of Action 
Erythromycin inhibits protein synthesis in susceptible organisms by reversibly 
binding to 50 S ribosomal subunits, thereby inhibiting translocation of aminoacyl 
transfer-RNA and inhibiting polypeptide synthesis. Antagonism has been 
demonstrated in vitro between erythromycin, lincomycin, chloramphenicol, and 
clindamycin. 
The exact mechanism by which erythromcyin reduces lesions of acne vulgaris is 
not fully known; however, the effect appears to be due in part to the antibacterial 
activity of the drug. 
Benzoyl peroxide has a keratolytic and desquamative effect which may also 
contribute to its efficacy. Benzoyl peroxide has been shown to be absorbed by the 
skin where it is converted to benzoic acid. 
NOTES 
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acne infection – ҳуснбузар инфекцияси – инфекция угрей 
non-inflammatory – яллиғланишсиз – без воспаления 
nodules – тугунлар - узелки 
disfiguring – ўсишдаги сезиларли етишмовчилик - 
permanent scarring – яранинг узоқ вақт битиши – долговременное рубцевание 
peeling – терининг пўст ташлаши – отшелушивание кожи 
oiliness – ѐғлилик - жирность 
tenderness of the skin – терининг юпқалашуви – истончение кожи