Application of Solution nmr spectroscopy to Study Protein Dynamics



Download 1,51 Mb.
Pdf ko'rish
bet1/22
Sana01.01.2022
Hajmi1,51 Mb.
#299570
  1   2   3   4   5   6   7   8   9   ...   22
Bog'liq
entropy-14-00581



Entropy

 

2012



14

, 581-598; doi:10.3390/e14030581



 

 

entropy



ISSN 1099-4300 

www.mdpi.com/journal/entropy 



Review 

Application of Solution NMR Spectroscopy to Study Protein 

Dynamics 

Christoph Göbl 

1

 and Nico Tjandra 

2,

Institute of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 



A-8010 Graz, Austria; E-Mail: christoph.goebl@uni-graz.at 

Laboratory of Molecular Biophysics, National Heart, Lung and Blood Institute, National Institutes 



of Health, 50 South Drive, Bethesda, MD 20892, USA 

*

  Author to whom correspondence should be addressed; E-Mail: tjandran@nhlbi.nih.gov; 

Tel.: +1-301-402-3029; Fax: +1-301-402-3405. 

Received: 30 January 2012; in revised form: 13 March 2012 / Accepted: 16 March 2012 /  

Published: 22 March 2012 

 

Abstract: 

Recent advances in spectroscopic methods allow the identification of minute 

fluctuations in a protein structure. These dynamic properties have been identified as keys to 

some biological processes. The consequences of this structural flexibility can be 

far-reaching and they add a new dimension to the structure-function relationship of 

biomolecules. Nuclear Magnetic Resonance (NMR) spectroscopy allows the study of 

structure as well as dynamics of biomolecules in a very broad range of timescales at atomic 

level. A number of new NMR methods have been developed recently to allow the 

measurements of time scales and spatial fluctuations, which in turn provide the 

thermodynamics associated with the biological processes. Since NMR parameters reflect 

ensemble measurements, structural ensemble approaches in analyzing NMR data have also 

been developed. These new methods in some instances can even highlight previously 

hidden conformational features of the biomolecules. In this review we describe several 

solution NMR methods to study protein dynamics and discuss their impact on important 

biological processes. 



Keywords: 

protein; protein structure; protein dynamics; protein interaction; solution NMR 

spectroscopy 

 

OPEN ACCESS




Entropy

 

2012



14

  

 



 


Download 1,51 Mb.

Do'stlaringiz bilan baham:
  1   2   3   4   5   6   7   8   9   ...   22




Ma'lumotlar bazasi mualliflik huquqi bilan himoyalangan ©hozir.org 2024
ma'muriyatiga murojaat qiling

kiriting | ro'yxatdan o'tish
    Bosh sahifa
юртда тантана
Боғда битган
Бугун юртда
Эшитганлар жилманглар
Эшитмадим деманглар
битган бодомлар
Yangiariq tumani
qitish marakazi
Raqamli texnologiyalar
ilishida muhokamadan
tasdiqqa tavsiya
tavsiya etilgan
iqtisodiyot kafedrasi
steiermarkischen landesregierung
asarlaringizni yuboring
o'zingizning asarlaringizni
Iltimos faqat
faqat o'zingizning
steierm rkischen
landesregierung fachabteilung
rkischen landesregierung
hamshira loyihasi
loyihasi mavsum
faolyatining oqibatlari
asosiy adabiyotlar
fakulteti ahborot
ahborot havfsizligi
havfsizligi kafedrasi
fanidan bo’yicha
fakulteti iqtisodiyot
boshqaruv fakulteti
chiqarishda boshqaruv
ishlab chiqarishda
iqtisodiyot fakultet
multiservis tarmoqlari
fanidan asosiy
Uzbek fanidan
mavzulari potok
asosidagi multiservis
'aliyyil a'ziym
billahil 'aliyyil
illaa billahil
quvvata illaa
falah' deganida
Kompyuter savodxonligi
bo’yicha mustaqil
'alal falah'
Hayya 'alal
'alas soloh
Hayya 'alas
mavsum boyicha


yuklab olish