Актуальные научные исследования в современном мире iscience. In. Ua

«MODERN SCIENTIFIC CHALLENGES AND TRENDS»
 
SCIENCECENTRUM.PL 
ISSUE 3 
ISBN 978-83-949403-3-1 
56
Karataeva L. A., Kurbanova M.B., Sadriddinova M. A. 
Tashkent Pediatric Medical Institute 
(Tashkent, Uzbekistan) 
 
SEPSIS AS A CAUSE OF DEATH 
In recent years, medicine has made significant progress in reducing child 
morbidity and mortality, but sepsis in newborns, especially in premature infants, 
remains the cause of many diseases and is often the cause of death. 
We examined the archive materials of the city children's hospital for the 
period 2010-2016, analyzed 58 cases of death of premature infants aged 5 days to 
3 months with clinic-morphological and laboratory confirmed intrauterine sepsis, 
including 38 boys (65.5%) and 20 girls (34.5%). In the perinatal period (up to 7 
days), 10 (17.2%) children died, in the late neonatal period (8-28) - 18 (31%) 
children, at the age of 1 to 2 months - 22 (37.9%) child, older than 2 months - 8 
(13.8%) children. 
In the group of deaths in the perinatal period there were 10 children 3-7 - 
days old, born with a weight of 1000 to 2500 gr. Clinically, all have been diagnosed 
with intracranial birth trauma. In 9 - intrauterine infection: a diagnosis of intrauterine 
hemorrhage or hemorrhages in the epidural fiber of the spinal canal. All have 
intracranial hemorrhages (subarachnoid, in the posterior cranial fossa) or 
hemorrhages in the epidural cellulose of the spinal canal of all children. Pneumonia, 
more often small-focal, and in 2-large-focal, complicating acute respiratory viral-
bacterial infection has been detected. All children had intrauterine sepsis with a 
primary focus in the bronchopulmonary tissues, septicemia (5) - the inflammatory 
process in the vessels was productive (4) or productive-purulent (1): the direct 
cause of death was pneumonia of the viral-bacterial and bacterial etiology (4) or 
massive hemorrhage into the cavity of the skull (1). In septicopyemia (5), the 
primary focus was characterized by the presence of ulcerative necrotic omphalitis 
(2) and purulent necrotic or purulent thrombovasculitis (4), there were metastatic 
purulent foci-leptomeningitis (2) and peritonitis (3), in one of the observations 
combined with fibrinose- purulent pleurisy. These processes also served as the 
direct cause of death. Small-focal serous or desquamate-leukocyte pneumonia, as 
a rule, played the role of an aggravating factor. All children of this group had 
myocardial, hepatic, renal dystrophy, in the majority (8) - blurred hyperplasia of the 
spleen with the presence in the pulp of myeloid elements, neutrophilic leukocytes. 
In the group of the deceased at the age of 8-28 days there were 18 children 
born with a weight of 900-2400 g. Clinically, 13 children had intracranial birth 
trauma, 12 had an acute respiratory viral-bacterial infection with pneumonia: 6 had 
pneumonia. The diagnosis of "intrauterine sepsis" was given to 14 children, 
including 4 with intrauterine infection. In the section, most children (15) have fresh 
and old hemosiderin hemorrhages - intracranial, epidural fiber of the spinal canal or 
a rusty shade of tissues and places of former hemorrhages.All those who died were 
diagnosed with pneumonia, including 11 as a complication of acute respiratory viral-
bacterial infection. Intrauterine sepsis in 14 children was the main disease, y: 4 - 
background. The inflammatory process in tissues with septicemia (13) was different: 
productive (5), productive-purulent (2), purulent or purulent-necrotic (6); the 

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