Advances in Molecular Electronics: a brief Review


Particulars containing ETO-NPs with different concentrations



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Particulars containing ETO-NPs with different concentrations.
 
Sample Particulars 
Cytotoxicity 
(%) 
Cell 
viability 
(%) 
Cytotoxic 
Reactivity 
Description 
Conc. 
(µg) 
ME1 

85 
15 
Severe 
10 
87 
13 
Severe 
50 
83 
17 
Severe 
75 
84 
16 
Severe 
100 
85 
15 
Severe 
Table 4(b):
 The percentage of Cytotoxicity and Cell viability of sample 
Particulars with different concentrations. 
Sample Particulars 
Cytotoxicity 
(%) 
Cell 
viability 
(%) 
Cytotoxic 
Reactivity 
Description 
Conc. 
(µg) 
DPEA 

87 
13 
Severe 
10 
88 
12 
Severe 
50 
88 
12 
Severe 
75 
85 
15 
Severe 
100 
85 
15 
Severe 
PPS 

86 
14 
Severe 
10 
89 
11 
Severe 
50 
83 
17 
Severe 
75 
84 
16 
Severe 
100 
83 
17 
Severe 
Results in (Table 4a) show that the synthesized ETO NP 
provides higher cytotoxicity and lesser cell viability. These results 
are almost agreed with the Cytotoxicity of DPEA and PPA 
against the MDA-MB-231 cell line which was shown in (Table 
4b). The maximum best result has been observed by adding the 10 
µg of synthesized ETO-NPs which killed the 87% of living 
MDA-MB-231 breast cancer cells. The overall result shows that 
the synthesized ETO-NP kills a minimum of 83% of MDA-MB-
231 breast cancer cells. 
Conclusion 
ETO-NPs with 60 to 66 nm have been successfully synthesized 
and characterized by XRD, UV–Visible, IR, PL spectrum, further 
the higher percentage of cytotoxicity against MDA-MB 231 and 
antimicrobial activity against micro bacteria and fungus has been 
investigated. Using UV-Vis spectrum, it was found that 4f orbital 
electrons cause ETO-NPs to absorb visible regions of light from 
380 to 700 nm and this photoluminescence property allows ETO-
NPs for designing the photoluminescence devices. XRD spectrum 
and TEM topography image with different magnifications 
confirmed the existence of ETO-NPs in the synthesized sample 
around the size range from 60 to 66 nm. This lesser size property 
of ETO-NP displayed a very good toxic activity against Bacillus 
SP, E.Coli, Aspergillus, and Mucor. Further, the antibacterial 
result concluded that the ETO-NP plays an effective (higher toxic 
activity) role against BACILLUS SP and Aspergillus than Mucor 
and E. coli Microbial pathogens. The synthesized ETO-NPs 
confirmed 87 % of cytotoxicity against the MDA-MB 231 cell 
line. 
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