A dictionary of Confusable Phrases: More Than 10,000 Idioms and Collocations

lose a fortune • lose one’s fortune
lose a fortune —lose an extremely large amount of money
(in gambling, etc.): He’s lost a fortune on the roulette tables
and his businesses are going bankrupt due to his massive debts.
lose one’s fortune —lose all of one’s financial wealth (through
misadventure, etc.): The first time he lost his fortune was in
1
9
1
5, when he declared himself bankrupt.
lose all reason • lose one’s reason
lose all reason —become irrational or illogical in one’s speech
or behavior: He lost all reason and started abusing his oppo-
nent.
lose one’s reason —lose one’s mental faculties; go crazy: It was
not unknown for men to become peculiar, or even completely
to lose their reason, in the vast spaces of Masailand.
lose heart • lose one’s heart
lose heart—become discouraged; give up hope: Don’t lose
heart if an ambition does not look like being realized.
Note: 
The expression is not antonymous in meaning to the
look someone in the face
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phrase have a heart—
1
. (usually imper.) be understanding and
sympathetic; be reasonable: Have a heart! I can’t possibly get
through that amount of work in such a short time. 2. (usually
negat.) be cruel or courageous enough to do smth. (also: have the
heart): When I got back, I felt better, but I didn’t have a heart
to tell him to go home.
lose one’s heart—fall in love with a person: He wanted to
buy a house before they got married, but while she was waiting
she lost her heart to another man.
lose hold of someone • lose hold over someone
lose hold of someone —(also: lose one’s hold of someone) 
1
. be
no longer able to physically grasp or hold a person: After a
struggle at midfield, Davis lost hold of Barrington, who then
scored to win the game. 2. lose power or control over a person:
He lost hold of her, and she moved to Capri, never to return
again to his life.
lose hold over someone —(also: lose one’s hold over someone) =
lose hold of someone 2: It is no matter to him that he loses his
hold over his children and his erstwhile fiancée.