A dictionary of Confusable Phrases: More Than 10,000 Idioms and Collocations

take it on the nose • take it through the nose
take it on the nose —(sl.) meet misfortune or defeat coura-
geously (also: take it on the chin): And as the 
1
980s saw labor
take it on the nose when choosing to strike, so the late 
1
990s
have been an era of high-stakes labor wins.
take it through the nose —(U.S. Drug users) inhale cocaine:
He went into the john, and most of us knew he had to take
it through the nose right then.
Note: 
The expression does not correlate in meaning with the
phrase pay through the nose—pay too much for smth.: It’s a
terrible car, and what annoys me is that I paid through the
nose for it.
take it out of someone • take it out on someone
take it out of someone —
1
. said of smth. that exhausts or
weakens a person: He needs rest. The excitement of the past
few days has taken it out of him. 2. exact satisfaction from a
person (for an offence): Now, you need to find a way to get
the money back or your boss will take it out of you.
take it out on someone —relieve one’s irritation, frustration,
etc. by attacking smb. who is innocent: I know you’re upset
at missing the train, but that’s no reason to take it out on the
porter.
take it up with someone • take up with someone
take it up with someone —ask a person to consider the matter
in question: Take it up with the insurance company, would
you? It’s not worth losing your no-claim bonus.
take up with someone —associate or become friendly with a
person, especially smb. undesirable: The woman he “took up
with” was likely enough to be married herself and of roughly
the same age as his own wife.
Note: 
The expression does not correlate in meaning with the
phrase take up for someone— support a person in an argument,
etc.: “My mom and sisters always took up for me,” Kyle said.
“They were always on my side…”