221
Good Laboratory Practice —
Establishing Validity
and Reliability
A.
Optimization ......................................................................................... 222
B.
Validation .............................................................................................. 223
1.
Levels of Validation ....................................................................... 224
2.
Validation of Methods for Comparison Evidence ...................... 225
3.
Validity vs. Reliability.................................................................... 225
4.
Is Validation Required? ................................................................. 228
C.
Quality Assurance and Quality Control.............................................. 228
1.
Quality Assurance.......................................................................... 228
2.
Quality Control ............................................................................. 228
a.
Standards and Controls ......................................................... 229
D.
Standardization ..................................................................................... 230
E.
Review.................................................................................................... 232
1.
Internal Review.............................................................................. 232
2.
Independent Review...................................................................... 233
3.
Elements of Review ....................................................................... 234
a.
What’s the Question? ............................................................. 234
b.
Documentation ...................................................................... 235
c.
What Evidence Was Tested?................................................... 236
d.
Data and Results..................................................................... 236
i. Standards and Controls ................................................... 236
ii. Second Blind Read ........................................................... 236
e.
Calculations ............................................................................ 237
f.
Interpretation and Conclusions ............................................ 237
g.
Validation................................................................................ 237
h.
The Big Picture....................................................................... 240
F.
Summary ............................................................................................... 240
References ...................................................................................................... 241
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222
Principles and
Practice of Criminalistics
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